Flexibility to Choose an Appropriate Dosing Regimen

The recommended dose for EYLEA in DR is 2 mg administered by intravitreal injection Q4 for the first 5 injections, followed by 2 mg Q8.1

Recommended dosing regimen for EYLEA® (aflibercept) Injection in patients  with diabetic retinopathy Recommended dosing regimen for EYLEA® (aflibercept) Injection in patients  with diabetic retinopathy

Although EYLEA may be dosed as frequently as 2 mg Q4 (≈every 25 days, monthly), additional
efficacy was not demonstrated in most patients when EYLEA was dosed Q4 compared with Q8.
Some patients may need Q4
(monthly) dosing after the first 20
weeks (5 months).

Trust the #1 prescribed anti-VEGF FDA approved for WET AMD, DME, and  MEfRVO. IBM Truven MarketScan data: number of injections administered  from Q4 2018 through Q3 2019; Data on file
Trust the #1 prescribed anti-VEGF FDA approved for WET AMD, DME, and  MEfRVO. IBM Truven MarketScan data: number of injections administered  from Q4 2018 through Q3 2019; Data on file

Q4, every 4 weeks; Q8, every 8 weeks;

Only EYLEA Is Approved to Treat 4 VEGF-Driven Retinal Diseases With 1 Single-Dose–Strength PFS

The pre-filled syringe (PFS) offers a more convenient way to prepare EYLEA for administration when compared with vials1

  • Fewer components to handle
  • Helps eliminate multiple preparation steps

One dosage strength may
help1

  • Simplify ordering and billing
  • Streamline inventory management
EYLEA® (aflibercept) Injection For Intravitreal Injection packaging and syringe EYLEA® (aflibercept) Injection For Intravitreal Injection packaging and syringe

Preparation of the single-dose, pre-filled syringe for intravitreal administration

VEGF, vascular endothelial growth factor.

A demonstrated safety profile1

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References
  1. EYLEA® (aflibercept) Injection full U.S. Prescribing Information. Regeneron Pharmaceuticals, Inc. March 2021.
  2. Data on file. Regeneron Pharmaceuticals, Inc.