logo logo FDA Approved November 2011
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A legacy of clinical experience

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10 years of extensive real-world experience1

In My Eyes by Regeneron logo. In My Eyes by Regeneron logo.

>16 million doses administered to >1.3 million eyes since launch (and counting)9

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8 phase 3 clinical trials, including >3000 EYLEA-treated patients across all approved indications: Neovascular (Wet) Age-Related Macular Degeneration (AMD), Macular Edema following Retinal Vein Occlusion (MEfRVO), Diabetic Macular Edema (DME), and Diabetic Retinopathy (DR)1,9

EYLEA® (aflibercept) Injection pre-filled syringe and packaging. EYLEA® (aflibercept) Injection pre-filled syringe and packaging.
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    AMD, Age-Related Macular Degeneration; anti-
    VEGF, anti–vascular endothelial growth factor;
    DME, Diabetic Macular Edema; DR, Diabetic
    Retinopathy; MEfRVO, Macular Edema following
    Retinal Vein Occlusion (includes Branch Retinal
    Vein Occlusion [BRVO] and Central Retinal Vein
    Occlusion [CRVO]).
References
  1. EYLEA® (aflibercept) Injection full U.S.
    Prescribing Information. Regeneron
    Pharmaceuticals, Inc. June 2021.
  2. Heier JS, Brown DM, Chong V, et al; for the
    VIEW 1 and VIEW 2 Study Groups. Intravitreal
    aflibercept (VEGF Trap-Eye) in wet age-
    related macular degeneration. Ophthalmology.
    2012;119(12):2537-2548. doi:10.1016/
    j.ophtha.2012.09.006
  3. Schmidt-Erfurth U, Kaiser PK, Korobelnik JF, et
    al. Intravitreal aflibercept injection for
    neovascular age-related macular
    degeneration: ninety-six-week results of the
    VIEW studies. Ophthalmology.
    2014;121(1):193-201. doi:10.1016/
    j.ophtha.2013.08.011
  4. Brown DM, Schmidt-Erfurth U, Do DV, et al.
    Intravitreal aflibercept for diabetic macular
    edema: 100-week results from the VISTA and
    VIVID studies. Ophthalmology.
    2015;122(10):2044-2052. doi:10.1016/
    j.ophtha.2015.06.017
  5. Campochiaro PA, Clark WL, Boyer DS, et al.
    Intravitreal aflibercept for macular edema
    following branch retinal vein occlusion: the
    24-week results of the VIBRANT study.
    Ophthalmology. 2015;122(3):538-544.
    doi:10.1016/j.ophtha.2014.08.031
  6. Boyer D, Heier J, Brown DM, et al. Vascular
    endothelial growth factor Trap-Eye for
    macular edema secondary to central retinal
    vein occlusion: six-month results of the phase
    3 COPERNICUS study. Ophthalmology.
    2012;119(5):1024-1032. doi:10.1016/
    j.ophtha.2012.01.042
  7. Holz FG, Roider J, Ogura Y, et al. VEGF Trap-
    Eye for macular oedema secondary to central
    retinal vein occlusion: 6-month results of the
    phase III GALILEO study. Br J Ophthalmol.
    2013;97(3):278-284. doi:10.1136/
    bjophthalmol-2012-301504
  8. Wykoff CC. Intravitreal aflibercept for
    moderately severe to severe non-proliferative
    diabetic retinopathy (NPDR): 2-year outcomes
    of the phase 3 PANORAMA study. Data
    presented at: Angiogenesis, Exudation and
    Degeneration Annual Meeting; February 8,
    2020; Miami, FL.
  9. Data on file. Regeneron Pharmaceuticals, Inc.