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Complete Product Support—Guiding
You Through Ordering and Returns

How to order EYLEA® (aflibercept) Injection

EYLEA is available through a number of different sources. Contact one of our authorized distributors to order EYLEA and receive it by the next business day.* If instructed by the payer, you may also obtain EYLEA through our network of specialty pharmacy providers.

*Orders received prior to 7 pm Eastern Time Monday–Thursday are typically processed on the same day and scheduled for delivery the next business day. Orders received on Friday will typically be delivered the following Monday.

Authorized Distributors

Regeneron does not recommend the use of any particular listed distributor. Subject to distributor qualification.

  • Credit cards are accepted by these distributors for EYLEA® (aflibercept) Injection purchases



Specialty Pharmacy Providers

Pharmacy Providers

Regeneron does not recommend the use of any particular listed distributor. Subject to
distributor qualification.

Have a question about distributors or specialty pharmacies?
Contact our specialists at 1-855-EYLEA4U (1-855-395-3248), Option 5,
Monday–Friday 9 AM–8 PM Eastern Time.

Setting Up a Distributor Account

To set up a distributor account, follow the step-by-step process shown for each distributor. Credit cards for EYLEA® (aflibercept) Injection purchases are accepted by all these distributors.1,*,†

Besse Medical
CuraScript SD Specialty Distribution
McKesson Specialty Health
Avella Specialty Pharmacy
Product return information
In the event EYLEA is rendered unusable after purchase, product may be returned to Regeneron and replaced in appropriate circumstances. Returns are subject to adherence to Regeneron policies and procedures regarding the return of product and Regeneron’s right, in its sole discretion, to deny replacement when misuse is suspected.

Product Return Information

All product should be returned as a condition of replacement.*
Product Return


For returns of expired product or product damaged in shipment, contact your distributor for return. For
product complaints, call EYLEA4U at 1-855-EYLEA4U (1-855-395-3248), Option 3.
Have a question about distributors or specialty pharmacies?
Contact our specialists at 1-855-EYLEA4U (1-855-395-3248), Option 3,
Monday–Friday 9 AM–8 PM Eastern Time.

Questions about applying for coverage, eligibility criteria, or denied claims?
Call EYLEA4U® at 1-855-EYLEA4U (1-855-395-3248), Option 4, Monday–Friday 9 AM–8 PM Eastern Time.
IMPORTANT SAFETY INFORMATION FOR EYLEA® (aflibercept) INJECTION
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  • EYLEA® (aflibercept) Injection is contraindicated in patients with ocular or periocular infections, active intraocular inflammation, or known hypersensitivity to aflibercept or to any of the excipients in EYLEA.
  • Intravitreal injections, including those with EYLEA, have been associated with endophthalmitis and retinal detachments. Proper aseptic injection technique must always be used when administering EYLEA. Patients should be instructed to report any symptoms suggestive of endophthalmitis or retinal detachment without delay and should be managed appropriately. Intraocular inflammation has been reported with the use of EYLEA.
  • Acute increases in intraocular pressure have been seen within 60 minutes of intravitreal injection, including with EYLEA. Sustained increases in intraocular pressure have also been reported after repeated intravitreal dosing with VEGF inhibitors. Intraocular pressure and the perfusion of the optic nerve head should be monitored and managed appropriately.
  • There is a potential risk of arterial thromboembolic events (ATEs) following intravitreal use of VEGF inhibitors, including EYLEA. ATEs are defined as nonfatal stroke, nonfatal myocardial infarction, or vascular death (including deaths of unknown cause). The incidence of reported thromboembolic events in wet AMD studies during the first year was 1.8% (32 out of 1824) in the combined group of patients treated with EYLEA. The incidence in the DME studies from baseline to week 52 was 3.3% (19 out of 578) in the combined group of patients treated with EYLEA compared with 2.8% (8 out of 287) in the control group; from baseline to week 100, the incidence was 6.4% (37 out of 578) in the combined group of patients treated with EYLEA compared with 4.2% (12 out of 287) in the control group. There were no reported thromboembolic events in the patients treated with EYLEA in the first six months of the RVO studies.
  • Serious adverse reactions related to the injection procedure have occurred in <0.1% of intravitreal injections with EYLEA including endophthalmitis and retinal detachment.
  • The most common adverse reactions (≥5%) reported in patients receiving EYLEA were conjunctival hemorrhage, eye pain, cataract, vitreous floaters, intraocular pressure increased, and vitreous detachment.
IMPORTANT PRESCRIBING INFORMATION FOR EYLEA® (aflibercept) INJECTION

EYLEA® (aflibercept) Injection is indicated for the treatment of patients with

  • Neovascular (Wet) Age-related Macular Degeneration (AMD): The recommended dose is 2 mg administered by intravitreal injection every 4 weeks (monthly) for the first 12 weeks (3 months), followed by 2 mg once every 8 weeks (2 months). Although EYLEA may be dosed as frequently as 2 mg every 4 weeks (monthly), additional efficacy was not demonstrated when EYLEA was dosed every 4 weeks compared to every 8 weeks.
  • Macular Edema following Retinal Vein Occlusion (RVO): The recommended dose is 2 mg administered by intravitreal injection every 4 weeks (monthly).
  • Diabetic Macular Edema (DME) and Diabetic Retinopathy (DR) in Patients with DME: The recommended dose is 2 mg administered by intravitreal injection every 4 weeks (monthly) for the first 5 injections, followed by 2 mg once every 8 weeks (2 months). Although EYLEA may be dosed as frequently as 2 mg every 4 weeks (monthly), additional efficacy was not demonstrated when EYLEA was dosed every 4 weeks compared to every 8 weeks.

Please see the full Prescribing Information for EYLEA.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

The information provided in this site is intended only for healthcare professionals in the United States. The products discussed herein may have different product labeling in different countries.

EYLEA and EYLEA4U are registered trademarks of Regeneron Pharmaceuticals, Inc.

777 Old Saw Mill River Road, Tarrytown, NY 10591
US-LEA-1934

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